Meeting Archive:
17-Beta Estradiol Attenuates Hypoxic Pulmonary Hypertension via Estrogen Receptor-mediated Effects.

This webinar has already occured, but the recording will be available soon on the PHA Online University (

Meeting Description:

The PHA Online University is proud to present this webinar featuring Tim Lahm, MD who will be discussing the results from his group’s recent publication in the American Journal of Respiratory and Critical Care Medicine. 

Women are more frequently diagnosed with pulmonary arterial hypertension (PAH), but despite this, they also exhibit better right ventricular function and higher survival rates than men.  A better understanding of the effects of sex hormones on the pulmonary vascular system is still needed both to explain the observed gender differences as well as to provide new avenues for future therapies.

Dr. Lahm and a group of investigators from the Richard L. Roudebush VA Medical Center and Indiana University School of Medicine in Indianapolis have been exploring the role that 17-beta Estradiol plays in tempering hypoxic PH. For this study, Dr. Lahm’s group focused on two questions:  1.) How does 17-beta estradiol exert its protective effects in hypoxia-induced PH? 2.) Does 17-beta estradiol work indirectly by being converted to estrogen metabolites or directly by activating the estrogen receptor?

Join us May 10th to learn more about the design of the study and the results drawn from the data.

For more information, read the abstract.  

Date: Thu, May 10, 2012
Time: 02:00 PM EDT
Duration: 1 hour
Host(s): Caitlin Flewellen
 Presenter Information
Tim Lahm, MD
Speaker Photo

Assistant Professor of Medicine
Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine
Indiana University
Roudebush VA Medical Center
Indianapolis, Ind.

Dr. Lahm attended medical school in Heidelberg, Germany, and moved to Indiana in 2002 for residency and fellowship. He has been on the faculty since 2008. Dr. Lahm’s research focuses on the effects of sex hormones on proliferative and remodeling processes in the pulmonary vasculature and Right Ventricle. In particular, he is interested in how sex hormones affect regulators of vasomotor tone, cell proliferation, autophagy, and growth factor secretion during acute or chronic hypoxia. He is collaborating with other researchers at Indiana University in studying exercise as a therapeutic intervention in animals and patients with PH. Dr. Lahm is Board-certified in Internal Medicine, Respiratory Diseases, and Critical Care Medicine. He is an awardee of a PHA/ATS/Pfizer Fellowship in PAH.