Meeting Archive:
Vaccine Manufacturing with Single-Use Technology: An Evaluation of Process Economy


Meeting Description:

As competition and cost pressure in the vaccine industry increase globally, the choice of manufacturing technology is becoming more important. Vaccine development and manufacture is particularly challenging, with technically complex R&D projects and production processes that use dated, inflexible, and costly methods. One route to success deploys single-use products that provide flexible processes, while keeping costs down in general. However, it is important to evaluate the effect of single-use technology on production costs in specific processes.

This webinar will present results from a process economy study comparing legacy vaccine processes using stationary culture and modern vaccine processes with single-use bioreactors. Detailed process schedules were developed and the impact of manufacturing technology on the vaccine production cost per dose was assessed.

An influenza vaccine process was used as a hypothetical tool for the study, but the results are also relevant for other vaccine processes. The upstream production scenarios were considered for roller bottles and stainless steel or single-use bioreactors using microcarriers. For the purification part of the process, traditional size exclusion chromatography (gel filtration) was compared to core bead chromatography. The outcome shows that modern technology can enable significant cost savings and a much simplified overall process. This process economy comparison will help identify the more cost-effective option based on a per-dose cost calculation.

Details
Date: Wed, May 4, 2016
Time: 11:00 AM EDT
Duration: 30 minutes
Host(s): BioProcess International
 Presenter Information
Dr. Mats Lundgren
Speaker Photo

Dr. Mats Lundgren has more than 25 years of experience in vaccinology. After earning his Ph.D. in Immunology, Cell, and Molecular Biology from the Karolinska Institute, Sweden, Dr. Lundgren completed post-doctoral training at the MRC Clinical Sciences Centre, Imperial College School of Medicine, UK. In his industrial career he has held positions at the bench and in management at Pharmacia (now part of GE), AstraZeneca, and several smaller biotechnology companies. In his current role as Customer Applications Director at GE Healthcare, he helps companies implement modern processes with the goal of achieving more efficient production and higher vaccine quality.