Meeting Archive:
An ASBMR Webinar on Systems Biology Approaches to Skeletal Disease

To listen to the recording and view the slides that were presented, click on the recording link on the right side of this screen. 

Meeting Description:

Reducing age-related fragility fractures remains a major objective of musculoskeletal research. Tremendous advances have been made toward noninvasively assessing when bone loss leads to reduced bone strength. However, a major unresolved challenge is being able to identify individuals at risk of fracturing prior to significant bone loss. Studying bone as a complex adaptive system may provide new insight into personalized prevention treatment strategies by providing a new way to think about bone. In this webinar, we will review the current status of how studying bone as a complex adaptive system may benefit fracture reduction efforts. We will also discuss how the pathways to fragility not only involve molecular mechanisms but also biomechanical mechanisms that may not be easily predicted based on knowledge of gene expression information alone. Finally, we will discuss future directions in how systems biology can be translated clinically.


As a result of this webinar participants will be able to:
  • Understand the current status of using systems biology approaches to study bone health and disease.
  • Appreciate that not all bones are constructed in the same way and that there are clinically important inter-individual differences in bone structure and function.
  • Appreciate that individuals may arrive at a fracture state through different biomechanical pathways.
Date: Thu, Mar 28, 2013
Time: 11:00 AM EDT
Duration: 1 hour
Host(s): American Society for Bone and Mineral Research
 Presenter Information
Karl Jepsen, Ph.D.
Speaker Photo

Dr. Karl Jepsen is Professor and Associate Chair of Research for the Department of Orthopaedic Surgery at the University of Michigan. His background is in Bioengineering. Dr. Jepsen's research group focuses on understanding how complex physiological systems such as bone establish function during growth and maintain function during aging. Developing a better understanding of how complex systems work is expected to benefit efforts to reduce fracture risk by identifying the genetic and environmental factors that impair (or promote) specific components of the functional adaptation process that compromise (or improve) musculoskeletal health.