Meeting Archive:
Unlocking the Potential for Efficiency in Downstream Bioprocesses

Meeting Description:

Improvements in productivity and efficiency are ranked as the single most important area on which the biomanufacturing industry should focus its efforts (1). These improvements are relevant for both existing and new facilities, and agility and flexibility in production are key elements. Novel technologies and innovative process strategies, such as intensified processing, enable more efficient biomanufacturing operations, even for existing facilities.

In this webinar, we will showcase multiple examples of process intensification solutions as means for achieving efficiency in downstream processes. One such solution of interest is automated chromatography column packing. By moving away from pack-in-place methodology, column packing can be simplified, saving both time and labor resources. Automated packing will also help prevent column packs from falling outside of specifications.

Another area of interest is improved buffer management through in-line conditioning. Working with buffer stock concentrates, instead of ready-made buffers, will allow for a reduced footprint and time savings. Floor space requirements in classified areas can be reduced even further by approaches such as connected or continuous downstream processing. These solutions can even enable improved product quality if a process is run in steady-state. Case studies and process economy gains for these process intensification solutions will be highlighted during the webinar.

[1] 12th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity,BioPlan Associates Inc. (2015)

Date: Wed, May 18, 2016
Time: 11:00 AM EDT
Duration: 30 minutes
Host(s): BioProcess International
 Presenter Information
Madhu Raghunathan
Speaker Photo

Madhu Raghunathan is Product Strategy Leader for Downstream Bioprocess Hardware equipment at GE Healthcare. In his current role, he helps companies identify opportunities for greater efficiency in their downstream processes. Previously, he was Market Development Leader for the Asia-Pacific region and Global Product Manager for a portfolio of hardware equipment, both within the Bioprocess division at GE. His expertise has been in defining, developing, launching, and managing products spanning bioprocessing, medical devices, and industrial automation markets. Mr. Raghunathan has a Master’s degree in Engineering from the University of Cincinnati, USA, and an MBA in Finance from the Indian School of Business, India.